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Cola before bed: 33 mg of caffeine and how long it lasts

Updated October 3, 2026 · Sources: FDA · USDA FoodData Central · Mayo Clinic figures · Drake 2013 · IOM 2001

Short answer

33 mg

per 12 fl oz (355 ml) can — half of it is still in you 5 hours later. About 2 hours to drop under 25 mg.

Reported range30–40 mgby brand and preparation
Share of FDA 400 mg/day8%healthy adults

General information from population studies (NIH, CDC, NSF, AASM). It is not medical advice and does not replace a clinician who knows you.

A 12 fl oz (355 ml) can serving of cola has roughly 33 mg of caffeine (reported range 30–40 mg). That makes it a light source: 8% of the FDA's 400 mg daily guideline in one serving.

Caffeine left after one cola (33 mg)
0h2h4h6h8h10h12h33178half gone at 5 h

Half-life 5 h (IOM 2001); shaded band = FDA's 4–6 h · as of October 3, 2026

How long cola stays in your system

Caffeine leaves the body by halves: five hours after a serving about 17 mg remains, after ten about 8 mg. Crossing below 25 mg takes roughly 2 hours at the average rate.

The half-life is an average. Between people it runs from about 1.5 to 9.5 hours: smokers clear caffeine faster; pregnancy, oral contraceptives and some medicines slow it. The curve above is a model of a typical adult, not a measurement of you.

Last cola for common bedtimes

Bedtime6 h beforemg left at bedtime if drunk 6 h beforemg left if drunk 3 h before
9:00 pm3:00 pm14 mg22 mg
9:30 pm3:30 pm14 mg22 mg
10:00 pm4:00 pm14 mg22 mg
10:30 pm4:30 pm14 mg22 mg
11:00 pm5:00 pm14 mg22 mg
11:30 pm5:30 pm14 mg22 mg
12:00 am6:00 pm14 mg22 mg
12:30 am6:30 pm14 mg22 mg
1:00 am7:00 pm14 mg22 mg

6-hour line from Drake et al. 2013 (400 mg at 6 h before bed cut sleep by >1 h) · 5-hour half-life · as of October 3, 2026

What the 6-hour rule is based on

One controlled trial (Drake and colleagues, 2013) gave 400 mg of caffeine — about four cups of brewed coffee — at bedtime, three hours before and six hours before, and measured sleep in a lab. Even the six-hour dose cut total sleep by more than an hour, and participants did not report feeling the difference. A single cola is a fraction of that dose, so the effect is likely smaller, but the direction is the same.

A brown ceramic cup of coffee on a table
Photo by Jakub Dziubak on Unsplash

Sources

  1. Caffeine content for coffee, tea, soda and more — Mayo Clinic
  2. Spilling the Beans: How Much Caffeine is Too Much? — U.S. Food and Drug Administration
  3. FoodData Central — U.S. Department of Agriculture
  4. Caffeine Effects on Sleep Taken 0, 3, or 6 Hours before Going to Bed — J Clin Sleep Med 9(11):1195-1200, 2013 (Drake C. et al.)
  5. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations — National Academies Press, 2001

General information from population studies (NIH, CDC, NSF, AASM). It is not medical advice and does not replace a clinician who knows you.